Molecular flow and wall collision age distributions

The use of storage cells has become a standard technique for internal gas targets in conjunction with high energy storage rings. In case of spin-polarized hydrogen and deuterium gas targets the interaction of the injected atoms with the walls of the storage cell can lead to depolarization and recombination. Thus the number of wall collisions of the atoms in the target gas is important for modeling the processes of spin relaxation and recombination. It is shown in this article that the diffusion process of rarefied gases in long tubes or storage cells can be described with the help of the one-dimensional diffusion equation. Mathematical methods are presented that allow one to calculate collision age distributions (CAD) and their moments analytically. These methods provide a better understanding of the different aspects of diffusion than Monte Carlo calculations. Additionally it is shown that measurements of the atomic density or polarization of a gas sample taken from the center of the tube allow one to determine the possible range of the corresponding density weighted average values along the tube. The calculations are applied to the storage cell geometry of the HERMES internal polarized hydrogen and deuterium gas target. Received 9 July 2001 and Received in final form 18 September 2001     

空间目标红外辐射特性研究

利用目标的红外光谱特性进行目标探测和识别是一种有效的方法。以空间卫星为目标,研究了其红外辐射特性形成的机理;利用所建立的数学模型,仿真了空间目标在探测面上所形成的红外光谱特性曲线;分析了模型中各参数对目标光谱特性的影响程度和卫星目标的红外光谱曲线。     

聚酰胺酸合成工艺研究

 采用超声波在线测量溶液粘度的方法，研究了合成聚酰胺酸过程中实验条件的影响，并对实验结果进行分析，由此确定了合成高分子量聚酰胺酸的最佳实验条件。研究表明：在加料次序为先加二胺后加二酐（二酐与二胺的摩尔比为1.01～1.02：1）、试剂中含水量尽可能少，反应温度0～5℃、反应时间以溶液粘度到达最大值为止的条件下，所合成的聚酰胺酸溶液粘度最大，可满足惯性约束聚变（ICF）充气腔靶端口膜的需要。     

UNIQUENESS PROBLEM WITH TRUNCATED MULTIPLICITIES OF MEROMORPHIC MAPPINGS FOR MOVING TARGETS

In this article,two uniqueness theorems of meromorphic mappings on moving targets with truncated multiplicities are proved.     

红外图像掠海小目标的检测算法研究

针对红外图像掠海小目标信噪比低，且易受到水天线和背景杂波干扰的特点，提出了一种红外掠海小目标的提取与检测算法。该方法的特点是：首先采用中值滤波来减小噪声，并提出了差方和算法，用以抑制背景噪声并对目标增强；再采用了图像行扫描法有效地滤除水天线；最后通过弱化背景边缘和阈值分割等综合算法得到候选小目标。仿真结果表明，该算法达到了较好的效果。     

黑腔靶中超热电子特性研究

近几年来,在“神光”装置上进行了1.053μm激光与平面靶及一系列柱形黑腔靶相互作用实验。用一台多道滤波—荧光X光能谱仪(FFS)测得各种靶发射的超热X射线谱,由谱推导超热电子温度T_h和超热电子总能量E_h当照射靶单束激光能量E_(tar)为400～670J、脉宽τ=650～1150ps时,发现黑腔内明显存在两群服从Maxwell分布高能电子(T_h=35～45keV;T_(hh)=150～350kev),而且E_(he)占E_(tar)的份额为10％～12％。实验还表明:腔内的E_(he)与非线性过程特征量(SRS)有较好的线性关系,因此推断出腔内超热电子产生的主要机制是受激Raman散射。在相同照射条件下,黑腔靶产生的超热电子比平面靶严重。     

黑腔靶X光转换,输运的定量测量

为了测量黑腔靶X光引光效率、转换效率,我们设计了相应的分解靶(泄漏靶)实验,1989～1992年在″神光″装置上共进行了四次漏靶分解实验,利用灵敏度作了绝对标定的平响应X光二极管对漏靶注入孔、引光孔流出的X光角分布进行了测量,测出了x光角分布,得到了黑腔靶X光转换效率为50％～60％,引光效率约6％,为以后辐射驱动内爆研究的理论计算和靶的优化设计提供了重要的数据。     

New antimalarial drugs

Approximately 40% of the world population live in areas with the risk of malaria. Each year, 300-500 million people suffer from acute malaria, and 0.5-2.5 million die from the disease. Although malaria has been widely eradicated in many parts of the world, the global number of cases continues to rise. The most important reason for this alarming situation is the rapid spread of malaria parasites that are resistant to antimalarial drugs, especially chloroquine, which is by far the most frequently used. The development of new antimalarial drugs has been neglected since the 1970s owing to the end colonialism, changes in the areas of military engagement, and the restricted market potential. Only in recent years, in part supported by public funding programs, has interest in the development of antimalarial drugs been renewed. New data available from the recently sequenced genome of the malaria parasite Plasmodium falciparum and the application of methods of modern drug design promise to bring significant development in the fight against this disease.     

Interaction Products of 12·5 Deuterons with Molybdenum and their Isolation Possibilities from Worn-out Cyclotron Parts

Using chemical separations and radiometric measurements medium-half-life irradiation products of molybdenum with 12.5 MeV deuterons were determined (⁹⁰Nb, ⁹²Nb, ^95mNb, ⁹⁵Nb, ⁹⁶Nb, ⁹⁹Mo, ^95mTc, ⁹⁶Tc, ^99mTc) as well as thick target yields for some of them: ⁹²Nb (0.22 μCi/μAh), ⁹⁵Nb(0.05 μCi/μAh), ⁹⁹Mo (64 μCi/μAh), ^95mTc(0.76 μCi/μAh), ⁹⁶Tc((62.5 μCi/μAh). Moreover isolation possibiities of radioactive preparations from removed worn-cut molybdenum parts of the U-120 cycletron are discussed.     

Structural Insights into the Interactions of Digoxin and Na+/K+-ATPase and Other Targets for the Inhibition of Cancer Cell Proliferation

Digoxin is a cardiac glycoside long used to treat congestive heart failure and found recently to show antitumor potential. The hydroxy groups connected at the C-12, C-14, and C-3′a positions; the C-17 unsaturated lactone unit; the conformation of the steroid core; and the C-3 saccharide moiety have been demonstrated as being important for digoxin’s cytotoxicity and interactions with Na⁺/K⁺-ATPase. The docking profiles for digoxin and several derivatives and Na⁺/K⁺-ATPase were investigated; an additional small Asn130 side pocket was revealed, which could be useful in the design of novel digoxin-like antitumor agents. In addition, the docking scores for digoxin and its derivatives were found to correlate with their cytotoxicity, indicating a potential use of these values in the prediction of the cancer cell cytotoxicity of other cardiac glycosides. Moreover, in these docking studies, digoxin was found to bind to FIH-1 and NF-κB but not HDAC, IAP, and PI3K, suggesting that this cardiac glycoside directly targets FIH-1, Na⁺/K⁺-ATPase, and NF-κB to mediate its antitumor potential. Differentially, digoxigenin, the aglycon of digoxin, binds to HDAC and PI3K, but not FIH-1, IAP, Na⁺/K⁺-ATPase, and NF-κB, indicating that this compound may target tumor autophagy and metabolism to mediate its antitumor propensity.